Our technology, included in our product aBSI and BONENAVI, is well documented in several studies.
2016 – Present – Clinical Utility of automated Bone Scan Index
Armstrong AJ et al. Phase 3 Assessment of the Automated Bone Scan Index as a Prognostic Imaging Biomarker of Overall Survival in Men With Metastatic Castration-Resistant Prostate Cancer: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 Jul 1;4(7):944-951
Armstrong AJ et al. Assessment of the bone scan index in a randomized placebo-controlled trial of tasquinimod in men with metastatic castration-resistant prostate cancer (mCRPC). Urol Oncol. 2014 Nov;32(8):1308-16.
Anand A et al. Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide. EJNMMI Res. 2016 Dec;6(1):23.
Reza M et al. Bone Scan Index as an Imaging Biomarker in Metastatic Castration-resistant Prostate Cancer: A Multicentre Study Based on Patients Treated with Abiraterone Acetate (Zytiga) in Clinical Practice. European Urology Focus, In Press, Corrected Proof, Available online 9 March 2016
2013 – 2017 – Validation of Novel automated platform
Ulmert D, Kaboteh R, Fox JJ, Savage C, Evans MJ, Lilja H, Abrahamsson PA, Björk T, Gerdtsson A, Bjartell A, Gjertsson P, Höglund P, Lomsky M, Ohlsson M, Richter J, Sadik M, Morris MJ, Scher HI, Sjöstrand K, Yu A, Suurküla M, Edenbrandt L, Larson SM. A novel automated platform for quantifying the extent of skeletal tumour involvement in prostate cancer patients using the Bone Scan Index. Eur Urol. 2012 Jul;62(1):78-84. doi: 10.1016/j.eururo.2012.01.037. Epub 2012 Jan 27. PubMed PMID: 22306323; PubMed Central PMCID: PMC3402084
Anand A et al. A Pre-Analytical Validation Study of Automated Bone Scan Index: Effect on Accuracy and Reproducibility due to the Procedural Variabilities in Bone Scan Image Acquisition. J Nucl Med. 2016 Jul 21. [Epub ahead of print]
Anand A et al. Analytic Validation of the Automated Bone Scan Index as an Imaging Biomarker to Standardize Quantitative Changes in Bone Scans of Patients with Metastatic Prostate Cancer. J Nucl Med. 2016 Jan;57(1):41-5
2008 – 2009: Technology behind automated Bone Scan Index
Sjöstrand K, Ohlsson M, Edenbrandt L. Statistical regularization of deformation fields for atlas-based segmentation of bone scintigraphy images. Med Image Comput Assist Interv. 12 (Pt 1): 664-71, 2009.
Sadik M, Suurkula M, Höglund P, Järund A, Edenbrandt L. Improved classifications of planar whole-body bone scans using a computer-assisted diagnosis system: a multicenter, multiple-reader,multiple-case study. J Nucl Med. 50(3): 368-75, 2009.
Kaboteh R, Gjertsson P, Leek H, Lomsky M, Ohlsson M, Sjöstrand K, Edenbrandt L. Progression of bone metastases in patients with prostate cancer – automated detection of new lesions and calculation of bone scan index. EJNMMI Res. 2013 Aug 16;3(1):64. doi: 10.1186/2191-219X-3-64. PubMed PMID: 23947784; PubMed Central PMCID: PMC3751570